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protein design

Welcome to the Huang Lab at Stanford.

​The protein design field took ten years to find a foothold in designing de novo structures (i.e. achieving full control of modeling protein backbones and sequences) and finally matured as suggested by the recent wave of publications such that we are now closer to achieving atomic-precision design of custom-made protein structures to address biomedical problems. Many challenges remain, as we are still far from achieving the complexity and functionality that nature displays.

​We are building a strong interdisciplinary research program to bridge this gap. Our research combines both computational and experimental aspects of protein engineering.​

Find our lab on Twitter @possuhuanglab
tim barrel design

Internal Lab Page

We're located in the Shriram Center for Bioengineering at Stanford,
sharing a lab space together​ with the ​Bintu Lab.

News from the lab!

December 2024

We are excited to announce that TRACeR I and TRACeR II are now published to Nature Biotechnology!

October 2024

Congratulations to Haotian, who successfully defended her PhD thesis!

September 2024

Welcome to Josh, who is joining the lab as a Visting Student Researcher from ETH Zürich!

June 2024

Protpardelle: an all atom protein generative model, is now published to PNAS

May 2024

Welcome to Hyejin, Wyatt, and Yilin, who are joining the lab as PhD students!

November 2023

Congratulations to Andres, who successfully defended his PhD thesis!

May 2023

Our method, Protpardelle: an all-atom protein generative model, is now posted to bioRxiv

April 2023

Congratulations to Alex, who successfully defended his PhD thesis!

December 2022

Our method, the Sculptor algorithm, is now posted to bioRxiv.

June 2022

Congratulations to Raphael, who successfully defended his PhD thesis!

June 2022

Welcome to Braxton, who is joining the lab as a PhD student!

March 2022

Welcome to Gina, who is joining the lab as a PhD student!

March 2022

Our protein sequence designer paper is published to Nature Communications!

January 2022

Welcome to Jingjia, who is joining the lab as a PhD student!

March 2021

Congratulations to Namrata, who successfully defended her PhD thesis!

August 2020

Our study on generative modeling of immunoglobulin proteins is posted to bioRxiv.

April 2019

Welcome to Christian, who is joining the lab as a PhD student! He will be jointly advised by Rhiju Das.

March 2019

Welcome to Carla, who is joining the lab as a PhD student!

November 2018

Raphael's model for evaluating protein structures is posted on bioRxiv as a preprint.

September 2018

Namrata's work is accepted to NeurIPS 2018, a major deep learning conference.

August 2018

Welcome to Alex, who is joining the lab as a PhD student!

June 2018

Congratulations to Shankara, who is starting his new job at the Broad Institute!

May 2018

Namrata presents her generator work at ICLR 2018.

February 2018

Congratulations to Jamin, who is starting a new lab at Hongik University!

January 2018

Welcome to Kirsten and Shankara, who have joined the lab as masters students/research associates.

Summer 2017

Raphael, Andres, and Namrata join the lab as the first grad students!

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